In addition, several studies found that MKP-1 may inhibit the inflammatory response by inhibiting p65 nuclear transcription (Chen et al., 2015; Kovacs et al., 2019), and the level of p38 MAPK activity in severe asthma patients increases in alveolar macrophages, and the level of MKP-1 mRNA expression in hormone-induced cells is reduced (Bhavsar et al., 2008). The gene discussed is DUSP1; the disease is asthma.