Transgenic mice with increased activity of PKCƐ achieved by overexpression of a constitutively active PKCƐ isoform (Takeishi et al., 2000) or by expression of a cardiac specific PKCƐ activator (Mochly-Rosen et al., 2000) exhibited cardiac hypertrophy. The gene discussed is PRRT2; the disease is cardiac hypertrophy.