When HQC medicated serum (20%) was added to cultured RA FLS or CUL4B vectors were transfected after HQC medicated serum (20%) was added, it was found that HQC medicated serum (20%) could inhibit the expression of β-catenin and CCND1, but CUL4B vectors reversed the effects of HQC medicated serum (20%) (Figure 4I). This evidence concerns the gene CUL4B and rheumatoid arthritis.