AKT1 and lip and oral cavity carcinoma: In cisplatin-resistant human oral cancer CAR cells, resveratrol activates autophagy via regulating AMPK and Akt/mTOR pathways, by phosphorylating AMPKα on Thr172 and AMPKα and dephosphorylating Akt on Ser473 and mTOR on Ser2448, and ultimately inhibits CAR cell viability (Chang et al., 2017) (Figure 1B).