MAPK8 and cancer: Resveratrol may induce autophagic cell death by activating c-Jun N-terminal kinase (JNK) pathway, as well as inducing AMPK pathway and ultimately leading to inhibition of mTOR pathway (Puissant et al., 2010).Resveratrol was reported to trigger autophagy through suppressing Akt/mTOR and inducing p38-MAPK pathways in human non-small-cell lung cancer cells A549 and H1299, thereby hindering cancer cell proliferation (Wang et al., 2018b).