The M1 phenotype typically produces tumor necrosis factor (TNF), interleukin (IL)-12 and interferon-γ (IFN-γ) inducible chemokines C-X-C motif chemokine ligand (CXCL) 9 and CXCL10 to exert pro-inflammatory and antitumor effects, whereas M2 macrophages, mainly identified by the production of IL-10 and Arg-1, are known to inhibit inflammatory responses and promote tumor progression (Mantovani et al., 2002; Murray et al., 2014; Lee et al., 2019). Here, TNF is linked to neoplasm.