Furthermore, reduced activity of KCa3.1 in CD8+ peripheral blood T cells (PBTs) of HNSCC patients causes these cells to be hypersensitive to adenosine found in the tumor microenvironment, ultimately reducing their migratory abilities and restricting their infiltration into tumors (Chimote et al., 2013; Chimote et al., 2018). Here, KCNN4 is linked to head and neck squamous cell carcinoma.