Meanwhile, it is worth noting that, in two clinical investigations, Korean red ginseng failed to improve the insulin sensitivity of non-diabetic healthy overweight and obese adults, and oral ginsenoside Re therapy was unable to upregulate insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or newly diagnosed diabetes, which indicated that certain ginsenosides or ginseng processing drug may have no significant effect on the recovery of insulin sensitivity in obese patients (Reeds et al., 2011; Cho et al., 2013). Here, INS is linked to Impaired glucose tolerance.