Furthermore, eIF3a modulated the sensitivity of melanoma cells to vemurafenib by promoting the translation of PPP2R1B, and PPP2R1B further resulted in decreased ERK activity by dephosphorylating this kinase, indicating that the eIF3a/PPP2R1B/ERK axis was a key mediator of melanoma resistance to vemurafenib (Figure 7). This evidence concerns the gene PPP2R1B and melanoma.