BCHE and dementia: Finally, observational studies on the response of men and women to anti-dementia drugs are still controversial, Gallucci M (Gallucci et al., 2016) and Wattmo C’s (Wattmo et al., 2011) studies have pointed out that the response to cholinesterase inhibitors treatment and longitudinal cognitive outcomes were better in males, while Haywood WM et al. indicated there is no significant sex difference (Haywood and Mukaetova-Ladinska, 2006).