Recent research has shown that local RAS activation, Ang II generation, and NE release are inhibited by activating MC GPCRs and the consequent stimulation of the PKCε/ALDH2 pathway, leading to ventricular arrhythmias in myocardial ischemia (Marino and Levi, 2018). This evidence concerns the gene PRKCE and Ventricular arrhythmia.