It has been reported that the NFKBIA gene (that encodes IκBα) shows mono-allelic deletions in some GBM types, which is often lost in a subtype-specific manner in GBM, and this associates with increased levels of NF-κB as well as inferior prognosis of patients (Bredel et al., 2011). Here, NFKB1 is linked to glioblastoma.