NFKB1 and central nervous system cancer: Plant flavonol quercetin inhibits NF-κB transactivation in the U87 human glioma cell line at 20 μM and demonstrates antiproliferative effects, necrosis/apoptosis activation, and cell cycle arrest in the U138MG human glioma cell line with lower cytotoxicity to normal cells (Braganhol et al., 2006; Braganhol et al., 2007; Park and Min, 2011).