NFKB1 and cancer: Apigenin’s immunoregulatory property is induced via the suppression of PI3K/Akt/NF-κB signaling cascade (control of IKK and IκBα) signaling pathways in various cancers (Chang et al., 2015; Erdogan et al., 2016; Qin et al., 2016), which can further result in a decreased level of metastasis and invasion.