Even though NF-κB has been revealed to develop cancer by triggering and maintaining a pro-inflammatory microenvironment, however; constitutive activation of NF-κB seems to induce tumor initiation and progression through several mechanisms, including apoptosis, proliferation of cells, metastasis of tumor, angiogenesis, and metabolism reprogramming (Xia et al., 2014). This evidence concerns the gene NFKB1 and cancer.