Plant homeodomain finger protein 20 (PHF20, an effector protein that binds with methylated p65) is a newly identified NF-κB regulator in GBM, which averts phosphatase PP2A recruitment, therefore it prolongs the presence of an active species of NF-κB in case of GBM (Zhang et al., 2013). The gene discussed is RELA; the disease is glioblastoma.