The top ten overexpressed (p = 7.47E-05–2.97E-06) mRNAs in EGFR altered cohorts compared to non-altered cohorts were TRIM7, BARX2, CFAP43, TPBG, HPSE, GNB5, MARK3, FUT8-AS1, SS18, and KCNK1, while SMAD4, MBP, IER3IP1, OXCT1, ALKBH5, C18ORF25, WDR76, TYMS, LINC00909, and GPR3 were overexpressed in c-MET altered CRC cohorts (Supplementary Table 4). This evidence concerns the gene IER3IP1 and colorectal carcinoma.