Of importance, we analyzed concurrent gene alterations with c-MET/EGFR genetic alterations, and found that EGFR alteration co-occurred with genetic alterations of SMARCD2, TRIM7, MCMDC2, HNRNPUL1, BEST3, GRB10, PDE6C, and SNX19, while alterations of SLC22A2, DST, AKT3, and TAB2 co-occurred with c-MET alterations in CRC. Here, BEST3 is linked to colorectal carcinoma.