In addition to concurrent gene alterations in CRC patients, we found that the genetic alteration of EGFR was associated with overexpression of mRNA levels of TRIM7, BARX2, CFAP43, TPBG, HPSE, GNB5, MARK3, FUT8-AS1, SS18 and KCNK1, while genetic alteration of MET was associated with the overexpression of mRNA levels of SMAD4, MBP, IER3IP1, OXCT1, ALKBH5, C18ORF25, WDR76, TYMS, LINC00909, and GPR3 in CRC cohorts. This evidence concerns the gene SMAD4 and colorectal carcinoma.