ANG and disease recurrence: Previous studies have found ANG expression to be significantly high in cases with loco-regional recurrent disease in laryngeal squamous cell carcinoma (Marioni et al., 2014; Lovato et al., 2015); ANG expression ≥ 5.0% is considered a significant, independent, negative prognostic factor in terms of DFS (Chen et al., 2014; Yang et al., 2020).