Alzheimer’s disease pathology is also characterized by intracellular neurofibrillary tangles (NFT) and extracellular plaques of aggregated amyloid beta (Aβ) peptide which accumulate in vulnerable brain regions (Sennvik et al., 2000) and both AChE and BuChE have been found aggregated in the amyloid plaques along with Aβ (Darreh-Shori et al., 2009a,b). The gene discussed is ACHE; the disease is Alzheimer disease.