In the context of AD, Lanni et al. (2013) found that two Aβ peptides could suppress the expression of ZYX, thereby inhibiting the activity of HIPK2, and indirectly modulating apoptosis by inducing the unfolded conformation of p53 that impedes the normal apoptotic process in the presence of stimulation. This evidence concerns the gene HIPK2 and Alzheimer disease.