Although VTN and SRC were not identified as differential enrichment proteins, based on their relatively high betweenness centrality, we speculated that VTN and SRC might exert important anti-AD roles (as they belong to Cluster 5) by regulating several bridge proteins, and most importantly, they might constitute a regulatory axis together with the preceding two key proteins (C7 and ZYX). Here, C7 is linked to Alzheimer disease.