Several candidates for AD diagnosis were recently unearthed, such as synapse proteins (including synaptophysin, synaptopodin, and synaptotagmins), down-regulation of which might signal neuronal dysfunction (Goetzl et al., 2016), as well as NPTX2 (neuronal pentraxin 2), which maintains neuronal homeostasis (Goetzl et al., 2018; Watson et al., 2019). This evidence concerns the gene NPTX2 and Alzheimer disease.