Of particular relevance in adolescent use, some involve, though not limited to, GPR55 in epilepsies resulting from heterozygous mutation to the Scn1a gene (Kaplan et al., 2017), 5-HT1a receptors in anxiety (Gomes et al., 2011), depression (Linge et al., 2016), and protection against acute stressors (Resstel et al., 2009), and PPARs and TRPV receptors on digestive and gut health (Couch et al., 2019). This evidence concerns the gene HTR1A and depressive disorder.