Yang et al. (2011a) and Siopi et al. (2016) reported similar results in MOB using different cell proliferation markers as PSANCAM, DCX, and BrdU. Marked inhibition of neurogenesis has also been reported in the hippocampus of mice model of depression (Ayuob et al., 2018; Qi et al., 2018). This observation might be caused by elevation of plasma corticosterone in CUMS mice, which has antiproliferative effects (Ali et al., 2017; Tong et al., 2019). The gene discussed is DCX; the disease is depressive symptom measurement.