CUMS-induced depression, in this study, was accompanied with a significant elevation (F = 5.75, p = 0.003, n = 10/group) in the MDA level, as well as a significant reduction in serum SOD (F = 7.35, p < 0.001, n = 10/group), GPX (F = 20.57, p < 0.001, n = 10/group), and CAT (F = 11.02, p = 0.002, n = 10/group) compared to the control. This evidence concerns the gene SOD1 and major depressive disorder.