E3 ligase HERC1 (regulator of chromosome condensation 1-like domain-containing protein 1) deficiency presents with delayed and abnormal brain development in mouse model (Bachiller et al., 2015), and patients with HERC1 mutations present with thicker corpus callosum, seizures, intellectual disability, and other autism-resembling clinical symptoms (Ortega-Recalde et al., 2015; Aggarwal et al., 2016; Utine et al., 2017). This evidence concerns the gene HERC1 and Intellectual disability.