Hypoxia-inducible factor 1 subunit α (HIF-1α), a factor induced by hypoxia, was reported to directly regulate BACE1 transcription and is contributing to BACE1 upregulation in response to hypoxia in the pathogenesis of AD (Sun et al., 2006; Zhang et al., 2007). This evidence concerns the gene HIF1A and Alzheimer disease.