For example, blocking the FBXW7 mediated HSF1 and Mcl-1 degradation may effectively ameliorate defects in neuronal function in HD and PD, respectively, even though effective acceleration of HIF-1α, PS-1 and RCAN1 by targeting FBXW7-mediated degradation possibly provides curative effect on AD treatment (Figure 2). Here, HSF1 is linked to Huntington disease.