Also, some neurodevelopmental disorders such as focal cortical dysplasias, tuberous sclerosis complex and syndromic autism spectrum disorder (ASD) are thought to arise due to the effects of mTOR mutations during fetal development (Sato, 2016; Iffland and Crino, 2017; Salussolia et al., 2019). This evidence concerns the gene MTOR and tuberous sclerosis.