NALCN increased neuronal excitability and modulated a number of physiological functions, including respiratory rhythms in mice (Lu et al., 2007), locomotion of C. elegans (Jospin et al., 2007; Yeh et al., 2008), hypotonia, growth retardation, and the intellectual disability of NALCN mutant children (Cochet-Bissuel et al., 2014; Fukai et al., 2016; Campbell et al., 2018). This evidence concerns the gene NALCN and Intellectual disability.