Trials conducted on an Alzheimer's disease (AD) Tg2576 mouse model with overexpression of the 5-LO gene showed not only increased level of biomarkers, indicating astrocytes and microglia activation [by elevation of glial fibrillary acidic protein (GFAP) and CD45 concentration], but also enhanced amyloid-β (Aβ) aggregation (Chu et al., 2012). Here, GFAP is linked to early-onset autosomal dominant Alzheimer disease.