Deletion of SRF in postnatal ECs at P1–P4 induces a significant delay in the development of the superficial vascular plexus and absence of deep vascular plexus, resembling major characteristics of inherited human retinal pathologies such as retinopathy of prematurity (ROP) and familial exudative vitreoretinopathy (FEVR), including Norrie’s disease (Wang et al., 2012; Franco et al., 2013; Weinl et al., 2013). Here, SRF is linked to exudative vitreoretinopathy.