Disruption of interactions between the coagulation cascade and inflammation has been observed in SARS-CoV-2 infected patients; CAC is unique in that it presents with elevated fibrinogen, D-dimer levels, Von Willebrand factor (VWF), factor VIII and inflammatory cytokines that can induce a generalized thrombotic disorder (Iba et al., 2020). The gene discussed is VWF; the disease is thrombotic disease.