Thus, the coloboma mouse model, characterized by halved SNAP-25 levels (Hess et al., 1992), displays a hyperactive phenotype (Hess et al., 1992), associated with abnormal thalamic spike-wave discharges (Hess et al., 1995; Zhang et al., 2004; Faraone et al., 2005; Russell, 2007). The gene discussed is SNAP25; the disease is coloboma.