GPR83 and Anxiety: To date, no small molecule agonists or antagonists for this receptor have been identified, therefore we used a combination of GPR83 global knockout (KO) animals and GPR83 shRNA mediated local knockdown (KD) in the basolateral amygdala (BLA), central nucleus of the amygdala (CeA), and NAc to study the role of this receptor in anxiety-related behaviors.