These brain regions play a role in anxiety, display significant GPR83 expression, and form circuits that encode positive and negative affective valence (Stuber et al., 2011; Tye et al., 2011; Janak and Tye, 2015; Namburi et al., 2015; Tovote et al., 2015; Beyeler et al., 2016; Lueptow et al., 2018; Fakira et al., 2019). This evidence concerns the gene GPR83 and Anxiety.