GPR83 and Anxiety: One reason for this discrepancy between the effect of global knockout vs local knockdown in the BLA may be due to an imbalance in these outgoing circuitries, suggesting the GPR83 tone from BLA contributes more to the anxiolysis, since there is an increase in anxiety with loss of GPR83 in this region, while global KO of GPR83 expression offsets this change in amygdalar tone.