Moreover, caffeic acid is capable of disrupting energy homeostasis and regulating oxidative metabolism and glycolysis in cervical tumor cells by activating the AMPK signaling pathway and suppressing the expression of hypoxia inducible factor-1α (HIF-1α), glucose transporter type 1 (GLUT1), hexokinase 2 (HK2), protein kinase M (PKM), and lactate dehydrogenase (LDH) (110). Here, HK2 is linked to uterine cervix neoplasm.