In the KEGG analysis, ten pathways including ko04512 (ECM-receptor interaction), ko04010 (MAPK signaling pathway), ko05412 (arrhythmogenic right ventricular cardiomyopathy (ARVC)), ko04210 (apoptosis), and others were affected by laminin mutations in OC (Supplementary Figure S5D). The gene discussed is LAMB2; the disease is arrhythmogenic right ventricular cardiomyopathy.