Maltseva D et al. demonstrated that LAMA5 knockdown led to Wnt- and mTORC1-dependent partial dedifferentiation of colorectal carcinoma which, in turn, was related to the activation of endoplasmic reticulum stress (ERS) signaling pathways promoting 5-fluorouracil (5-FU) sensitivity. Here, LAMA5 is linked to colorectal carcinoma.