Our previous study verified that EndoA2 promoted H2O2-induced rat basilar artery smooth muscle cell apoptosis 18, Moreover, EndoA2 inhibited H2O2-induced H9C2 cardiomyocyte apoptosis by enhancing autophagy 21 and attenuated cardiac hypertrophy induced by angiotensin II 20 or isoproterenol 19. Here, AGT is linked to cardiac hypertrophy.