For example, lncRNA LINC00160 was proved to function as a tumor suppressor by inhibiting autophagy and drug resistance in HCC through miR-132/PIK3R3 pathway 45, while lncRNA H19 can serve as a tumor enhancer by inducing autophagy activation via the H19/SAHH/DNMT3B axis, and contributes to tamoxifen resistance in breast cancer 46. The gene discussed is PIK3R3; the disease is breast cancer.