We verified the gene and protein expression of the four m6A regulators screened in the collected samples from HCC clinical patients, and the results showed that compared with normal patients, KIAA1429, LRPPCC, RBM15b and YTHDF2 were up-regulated in HCC patients, which was more significant in A-HCC patients (Figure S1B-C). The gene discussed is VIRMA; the disease is hepatocellular carcinoma.