Given that DNMT1 and EZH2 are barely expressed in the control group but are significantly up-regulated by alcohol-treatment and significantly down-regulated after teniposide treatment, the results suggest that DNMT1 and EZH2 may be core proteins in the aetiology of A-HCC and highlight teniposide as a potential therapeutic drug. The gene discussed is EZH2; the disease is hepatocellular carcinoma.