CCNB2 and neoplasm: However, the migration potential was significantly inhibited by CA074, the inhibitor for Cathepsin B (Lenti-CCNB2+CA074 vs. Lenti-CCNB2: 47.9±5.57 vs. 69.5±3.91%, P=0.005), which suggested that Cathepsin B secreted from CCNB2-related senescent cells promoted tumor migration (Figure 8D, E).