With treatment of medium from Lenti-Vector, Lenti-CCNB2 and Lenti-CCNB2+CAY10650 (inhibitor of PGE2 secretion) cells, SASP cytokines from Lenti CCNB2 supernatant significantly facilitate the 3D tumor sphere formation of glioma cells (Lenti-CCNB2 vs. Lenti-Vector: 9.3±0.53 vs. 4.6±0.79%, P=0.001), while it was remarkedly inhibited by CAY10650 (Lenti-CCNB2+CAY10650 vs. Lenti-CCNB2: 6.9±0.85 vs. 9.3±0.53%, P=0.014) (Figure 9D, E). The gene discussed is CCNB2; the disease is neoplasm.