Meanwhile, severe combined immunodeficient (SCID) mice that were continuously infused with IGF-1 early after Caki tumour cell inoculation exhibited higher intratumour IGFBP3 expression, a larger tumour size and a higher microvascular density, providing additional evidence that the upregulation of IGFBP3 may be involved in tumour viability and growth 20. Here, IGFBP3 is linked to neoplasm.