CASP3 and neoplasm: Compared with the control group, the xenograft tumours from mice treated with CVB exhibited an evident decrease in the levels of IGFBP3, p-AKT, p-STAT3, p-ERK, p-JNK, p-P38, Bcl-2, Snail, and Vimentin (Fig. 9E), while the levels of cleaved Caspase 3 and E-cadherin were increased.