In 2014, Lin et al. published a profound study delineating that IGFBP3 facilitates cancer cell survival by repairing the DNA double-strand breaks caused by genotoxic stress through an increase the autophosphorylation of DNA protein kinase catalytic subunit (DNA-PKcs) and the formation of nuclear EGFR-DNA-PKcs complexes 41. This evidence concerns the gene IGFBP3 and cancer.