AKT1 and breast carcinoma: For examples, TQ can retard the tumor growth of breast carcinoma by suppressing the PI3K/AKT axis 18; studies have also shown that TQ suppresses the A549 lung tumor cells proliferation by elevating the p53 expression and Bax/Bcl-2 ratio, and triggering the caspase 9 and caspase 3 at the same time 19.