CASP3 and cancer: Moreover, as a cleaved caspase 3 inhibitor, the co-treatment of Z-VAD-FMK (ZVF) with TQ significantly reversed the TQ induced increase of cleaved caspase3 and cleaved PARP proteins (Figure 2D), notably rescued the cancer cells viability (Figure 2E), and markedly reduced TQ evoked cell apoptosis (Figure 5F).