Shan et al. 137 revealed that the upregulation of NEAT1 in bladder cancer promotes bladder cancer cell proliferation and inhibits cell apoptosis and cell arrest by sponging miR-410, thereby upregulating the expression of high mobility group box 1 (HMGB1), an accelerator for tumor progression by its immune protective and suppressive functions 138. This evidence concerns the gene HMGB1 and urinary bladder carcinoma.