NEAT1 and neoplasm: Moreover, overexpression of NEAT1 could inhibit CC cell apoptosis and EMT by targeting miR-133a, thereby increasing the expression of SRY-box transcription factor 4 (SOX4), an important epigenetic regulator in tumorigenesis 88, 89, and targeting miR-361 to increase expression of the 90-kDa heat shock proteins (HSP90s), an essential factor contributing to the tumor metastatic phenotype 90,91.