Gao et al. 115 reported that NEAT1 upregulation in MM patients promoted M2 macrophage polarization, a contributor to tumor progression that promotes angiogenesis to support tumor growth 116, by upregulating the expression and release of B7-H3 and then activating JAK2/STAT3 signaling via direct targeting of miR-214. This evidence concerns the gene CD276 and neoplasm.