By upregulating the expression of sirtuin-1 (SIRT1) via miR-34a 67, glial cell-derived neurotrophic factor (GDNF) via miR-196a-5p 68, and VEGFA via miR-205-5p 69, NEAT1 enhanced CRC cell proliferation, colony formation, and invasive potential. The gene discussed is GDNF; the disease is colorectal carcinoma.