Researchers investigated the regulatory influence of the NEAT1/miRNA/target axis in AML progression; they found that NEAT1 expression was downregulated in AML cells and that overexpression of NEAT1 inhibited cell proliferation, migration, and invasion, decreased the number of cells in the G2/M phase, and significantly induced cell apoptosis through the NEAT1/miR-23a-3p/structural maintenance of chromosomes 1A (SMC1A) axis 103 and NEAT1/miR-338-3p/CREB3 regulatory factor (CREBRF) axis 104. Here, NEAT1 is linked to acute myeloid leukemia.