A study on the role of NEAT1 in RB progression revealed that NEAT1 expression levels were elevated in RB tissues and cells; NEAT1 knockdown significantly inhibited RB cell proliferation and migration and promoted cell apoptosis by competitively binding with miR-204 to regulate the expression of C-X-C chemokine receptor type 4 (CXCR4) 125. The gene discussed is NEAT1; the disease is retinoblastoma.