Furthermore, silencing of HDAC11 in Hodgkin lymphoma cells induces expression of OX40 ligand, which is known to be important for the development of an efficient anti-tumor response 147-149, and proinflammatory cytokines, including TNF-ɑ and IL-17, which generate an overall favorable anti-tumor response with more effector and fewer regulatory T cells 150. This evidence concerns the gene TNFSF4 and neoplasm.