In urothelial carcinoma of the bladder, NSUN2 targets the 3' untranslated region (3'-UTR) and stabilizes the mRNA of HGDF by generating the RNA m5C modification, while the reader YBX1 binds to the m5C region with the help of the partner protein ELAVL1 (an mRNA stability maintainer). The gene discussed is YBX1; the disease is bladder transitional cell carcinoma.