As the most well-known NSUN family menber, NSUN2 (yeast homologue TRM4) participates in cell cycle progression and tumor growth, probably by targeting at known C34, 48, 49, 50 of tRNA in a range of tumors, such as human squamous cell carcinoma and breast cancer 56, 57. The gene discussed is NSUN2; the disease is neoplasm.