For example, DNMT1 activity is increased by high level of specificity protein 1 (SP1)-induced endogenous p53 inactivation in lung cancer, while p53 is now better known for its anticancer effect than as an oncoprotein in various tumors, as it is associated with cell survival, invasion, tumor growth, metastasis, the EMT and multiple pro-oncogenic signaling pathways 129. Here, SP1 is linked to neoplasm.