NEDD4L and pulmonary fibrosis: Moreover, we identified that PR-619 treatment could alleviate the lung tissue lesions of IPF mice (Figure 5C), repress pulmonary fibrosis (Figure 5D), reduce the content of hydroxyproline in tissues (Figure 5E), and resulted in up-regulated compliance and down-regulated resistance of the lung (Figure 5F), whereas sh-NEDD4L could reverse the aforementioned effect of PR-619.