CDH2 and posterior cortical atrophy: To investigate whether N-cadherin/AR/NDRG1 signaling affects PCa progression, PC3-sh-CDH2/NC cells were transfected with an siRNA targeting NDRG1 (si-NDRG1, with si-NC as the negative control) and divided into the following four groups: shNC-siNC, shCDH2-siNC, shNC-siNDRG1, and shCDH2-siNDRG1.