However, in the course of further study, we found that N-cadherin, a downstream effector, could reversibly inhibit the expression of AR and NDRG1 in PCa cells, suggesting that N-cadherin is not only a downstream effector but that an interplay mechanism may exist between N-cadherin and NDRG1. The gene discussed is NDRG1; the disease is posterior cortical atrophy.