CD47 and neoplasm: CD47 expression is trigged by multiple transcriptional factors including NFκB, Myc, and HIF, etc 3, 11, 19, 20, while the SIRPα-CD47 axis blockade enhances phagocytosis by macrophages and DCs to activate innate immune response resulting in tumor regression 3, 7, 11, 12, 18, whereas the phagocytosis by DCs activates DNA-sensing cGAS-STING-INF-γ-mediated adaptive immune response leading to T cell priming 21-23, suggesting that inhibition of SIRPα-CD47 axis could enhance innate and adaptive antitumor immune response.