As APCs, DCs engulf cancer cells and tumor-derived DNA in DCs activates cGAS (cGAMP), a cytosolic DNA sensor, subsequently, activates the downstream cGAS-cGAMP-STING innate immune response that exhibits antitumor activity 23, 40, whereas highly expressed CD47 inhibits this signaling pathway in cancer cells leading to tumor immune escape 7, 8. Here, CGAS is linked to cancer.