CGAS and neoplasm: As APCs, DCs engulf cancer cells and tumor-derived DNA in DCs activates cGAS (cGAMP), a cytosolic DNA sensor, subsequently, activates the downstream cGAS-cGAMP-STING innate immune response that exhibits antitumor activity 23, 40, whereas highly expressed CD47 inhibits this signaling pathway in cancer cells leading to tumor immune escape 7, 8.