IFNA1 and viral infectious disease: vIRF-1 appears to play important roles in blocking IFN and other stress responses, such as mitochondria-mediated apoptosis via BH3-only-proteins (BIM and BID) and MAVS (also known as IPS-1, VISA, and Cardif), to virus infection and replication through inhibitory interactions with cellular signaling proteins [18–21].