MAP4K4 and familial pancreatic carcinoma: Once the stable cell lines were characterized, we used them to determine the impact of MLK3 phosphorylation by MAP4K4 on pancreatic cancer cell proliferation (Fig. 3d and Supplementary Fig. 2c), colony formation (Fig. 3e and Supplementary Fig. 2d), and cell migration (Fig. 3f and Supplementary Fig. 2e).