Since MAP4K4 inhibitor GNE-495 was able to arrest cell cycle progression of pancreatic cancer cells line (Fig. 5c, e) but not of the nontumorigenic cells (Fig. 5d), therefore we sought to determine the efficacy of GNE-495 on inducing cell death in pancreatic cells. Here, MAP4K4 is linked to familial pancreatic carcinoma.