CASP3 and pancreatic neoplasm: To re-confirm our IHC/IF results with pancreatic tissues from KPC mice, the saline or GNE-495-treated pancreatic tumor extracts were blotted with antibodies for MAP4K4, MLK3, PCNA, α-SMA, cleaved caspase 3, c-PARP, Bax, and Bcl2 (Fig. 7f).