CDK1 and familial pancreatic carcinoma: As shown in Fig. 5c, GNE-495 arrested pancreatic cancer cell line, Capan-1 in G2/M cell cycle stage (Fig. 5c) but not the nontumorigenic, HPNE cell line (Fig. 5d), which was also evident by decreased phosphorylation of CDK1 and expression of its associated Cyclin B in pancreatic cancer cell lines, Capan-1 (Fig. 5e) and PANC-1 (Supplementary Fig. 4b) but not in the normal pancreatic cell line, HPNE (Fig. 5e).