Crizotinib has been approved for use in ROS1-rearranged NSCLC based on the PROFILE 1001 study, which observed an objective response rate (ORR) of 72%, median progression-free survival (PFS) of 19.2 months, and median overall survival of 51.4 months among the 53 patients with ROS1-rearranged NSCLC included in the expansion cohort [8, 14]. The gene discussed is ROS1; the disease is non-small cell lung carcinoma.