PPARGC1A and Parkinson disease: Moreover, in the ROC analysis, the combination of HOXA-AS2 and PGC-1α showed a higher predictive value (AUC = 0.77, specificity = 75%, sensitivity = 70%) for PD and healthy controls than any individual marker (HOXA-AS2: AUC = 0.71, specificity = 70%, sensitivity = 62%; PGC-1α: AUC = 0.72, specificity = 70%, sensitivity = 68%) (Fig. 7E).