Consistent with the findings of our literature review, bioinformatics analysis, gain‐ and loss‐of‐function study, and molecular approaches, P53 was revealed to be the upstream regulator of miR‐15a, promoting its expression and exerting anti‐HCC effect and GlcNAc OGT as the downstream target of miR‐15a. Here, TP53 is linked to hepatocellular carcinoma.