Next, to verify whether EZH2 was modified by glycosylation and whether glycosylation influences EZH2 in HCC cell lines, co‐IP assay was performed and the results indicated that OGT could interact with EZH2 in HCC‐LM3 and Huh‐7 cells (Figure 5E). This evidence concerns the gene OGT and hepatocellular carcinoma.