Mutations and gene methylation related to LC, such as mutations in TP53, EGFR, BRAF, ERBB2, PDGFRA and KRAS or methylation of PTGER4/SHOX2, were previously detected in plasma or cerebrospinal fluid of NSCLC and SCLC patients, both in early and late stages [4, 8, 9, 10]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.