APP and amyloidosis: Isolation of APAM followed by RNA sequencing and integrative omic analysis confirms that early amyloid plaque aggregation triggers localized APAM‐specific transcriptomic changes and mediates feed‐forward to accelerated APP amyloidogenic processing and other later‐appearing neurodegenerative pathologies including neuroinflammation, reactive astrocytosis, microglial phenotype switching, and neuronal death.