RHO and neoplasm: Previous studies have suggested that LPAR6 affects tumor biological functions through Gα12/13-Rho, adenylyl cyclase (AC)/cyclic adenosine monophosphate-dependent/protein kinase A (PKA), Ca2+-protein kinase C (PKC) pathways, and that it is regulated by nuclear receptor coactivator 3 (NCOA3) [10, 22].