While these data are indeed consistent with the pro-apoptotic effects of Bmi-1 knockdown reported in bladder cancer cells [45, 46], additional experiments are clearly needed to ascertain the modulatory influence of BA on Bmi-1 expression and activity, as well as the link between Bmi-1 and both autophagy and apoptosis in bladder cancer cells. Here, BMI1 is linked to urinary bladder carcinoma.