It is widely accepted that aberrant c-myc expression leads to an apoptotic response38–41 in healthy tissue preventing transformation and that addition of an additional genetic alteration that blocks the apoptotic response governs rapid oncogenic transformation.40 42 43 Interestingly, a synergistic effect of mTROC1 activation and c-myc was previously described in liver tumours and lymphomas.44 45 Thus, it seems reasonable that Kdm6a-dependent mTORC1 deregulation is the main driver of transformation in our system. The gene discussed is KDM6A; the disease is lymphoma.