Remarkably, we found a significant survival benefit of tumour bearing mice on Dox-withdrawal (figure 2B) and analyses of MRI time-courses showed rapid tumour progression in mice with sustained Kdm6a suppression, whereas tumours were stalled in mice with endogenous Kdm6a re-expression, however they eventually progressed at later time points (figure 2C). The gene discussed is KDM6A; the disease is neoplasm.