Kdm6a is part of the MLL3/MLL4 COMPASS-like complex, which epigenetically regulates gene expression by influencing chromatin accessibility on histone modifications.7 11 Thus, to interrogate potential target genes mediating the tumour suppressive activity of Kdm6a, we profiled the transcriptome of Myc;sgKdm6a cell lines. This evidence concerns the gene KMT2C and neoplasm.