Notably, these analyses revealed that solid cancers have the highest prevalence of these alterations, whereas previous studies that functionally analysed these proteins in tumourigenesis were focusing on haematological malignancies.19 23 37 We concentrated on KDM6A, as it showed the highest alteration frequencies, and identified by screening a large amount of human liver cancers that KDM6A protein expression was lost in about 30% of patients. Here, KDM6A is linked to liver cancer.