Immunohistochemical analyses of murine Myc;sgKdm6a liver tumours revealed increased phosphorylation of the mTORC1 downstream target S6RP (pS6RP) compared with Myc;sgTp53 liver tumours (figure 3D), indicating hyperactivation of mTORC1 in these tumours. This evidence concerns the gene MYC and neoplasm.