Despite the importance of PCSK9 and ASGR1 in lipid lowering and reduced CVD risk, there are currently no studies to suggest that ASGR1 and PSCK9 act in concert to impact lipid metabolism and/or atherosclerosis by modulating the binding/uptake of LDLc via the LDLR. The gene discussed is ASGR1; the disease is atherosclerosis.