In the subgroup analysis by each eye disease outcome, WHtR was associated with maculopathy (HR 1.48, 95% CI 1.25-1.75, P < 0.0001) and PDR (HR 1.22, 95% CI 1.02-1.45, P = 0.03) with or without laser or anti-VEGF treatment but not with vitreous hemorrhage (HR 1.14, 95% CI 0.83-1.55, P = 0.42) with or without vitrectomy. The gene discussed is VEGFA; the disease is vitreous hemorrhage.